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        Nc2Eye

           A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of retinoblastoma (RB)
ncRNA name hsa-miR-376a
ncRNA Category miRNA
Disease name retinoblastoma (RB)
Species Homo sapiens
Tissues/Cell_line RB cell line HXO-RB44
Methods flow cytometry, microarray, qRT-PCR, transfection, luciferase reporter assay, Western blot
Expression pattern down-regulated
Functional description ATO -induced apoptosis in retinoblastoma cells is part mediated by decreasing expression of miR-376a, which subsequently increased caspase-3 expression.
PubMed ID 23373993
Year 2013
Title Arsenic trioxide induced apoptosis in retinoblastoma cells by abnormal expression of microRNA-376a.
Drug-related ncRNA NO

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